16α-Hydroxycholic Acid: In Vivo Microbial Transformation Product of Cholic Acid
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چکیده
منابع مشابه
Cholic acid-modified polyethylenimine: in vitro and in vivo studies
Low-molecular-weight polyethylenimine has lower cytotoxicity than high molecular weight polyethylenimine, but it is not an efficient transfection agent because of limitations of DNA delivery into the cytoplasm. Therefore, in the present study, the hydrophobic modification of low-molecular-weight polyethylenimine (PEI 2 kDa [PEI2]) by cholic acid (ChA) was performed to form PEI2-ChA, and in vitr...
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In the title inclusion compound, 2C(24)H(40)O(5)·C(8)H(6)N(2), the unit cell contains two mol-ecules of cholic acid (3α,7α,12α-trihydr-oxy-5β-cholan-24-oic acid) and one mol-ecule of quinoxaline which implies disorder of the quinoxaline in the space group P2(1). The amphiphilic mol-ecules of cholic acid assemble, in an anti-parallel arrangement, via O-H⋯O hydrogen bonds, into typical corrugated...
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In attempting to apply the method described by Gregory and Pascoe (1929) to the determination of bile acids in bile, considerable difficulty was experienced because of the weakness of the blue color developed by cholic acid. Later it was found that because of a misprint in the original paper only one-fifth of the required amount of cholic acid was being used. Before this was known several attem...
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An obligate anaerobic organism capable of dehydroxylating cholic acid to deoxycholic acid and allocholic acid to allodeoxycholic acid was isolated from feces of the rabbit. It was a member of the bacteroides group (Gram-variable, nonsporulating anaerobes). The growth of the organism was inhibited by neomycin, 10-20 micro g/ml. The existence of this organism affords a satisfactory explanation fo...
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We previously reported that the 7 alpha-dehydroxylation of cholic acid appears to be carried out by a multi-step pathway in intestinal anaerobic bacteria both in vitro and in vivo. The pathway is hypothesized to involve an initial oxidation of the 3 alpha-hydroxy group and the introduction of a double bond at C4-C5 generating a 3-oxo-4-cholenoic bile acid intermediate. The loss of water generat...
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ژورنال
عنوان ژورنال: British Journal of Pharmaceutical Research
سال: 2013
ISSN: 2231-2919
DOI: 10.9734/bjpr/2014/3194